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时间:2013年10月11日

个人简介

浙江大学生物物理学国家重点学科带头人,教育部“长江学者”特聘教授,国家杰出青年基金获得者。现任浙江大学农业与生物技术学院副院长、原子核农业科学研究所所长、浙江省“核农学”重点研究实验室、农业部“核农学”重点开放实验室主任。兼任中国原子核农学会常务副理事长、中国空间科学学会生命起源与进化专业委员会副主任委员、浙江省原子核农学会理事长、浙江省核学会副理事长、浙江省辐射防护协会理事长等职。担任Food Chem Toxicol 和Front Evolut Genomics Microbiol 编委、《核农学报》主编、Science、PLoS One、Mol Microbiol、 Mol Cell Proteomics 等国际高影响力科学杂志的特邀论文评审专家。近年来主持国家自然科学基金重点项目、国家杰出青年基金、科技部国际合作重点项目、农业部公益性行业科研专项、科技部863重点课题、科技部973课题、转基因重大专项、国家新药创制重大科技专项等课题10余项。在Nature、P Natl Acad USA、Mol. Cell Proteomics、J. Biol. Chem.、Mol. Microbiol.、Oncogene 等重要国际期刊发表论文60余篇。申请发明专利7项,已授权发明专利3项。获省部级科学技术二等奖3项。研究成果“DNA修复开关基因的发现与鉴定”入选“2003年度中国高校十大科技进展”。

工作研究领域

  1. (1)DNA损伤和修复相关的基因组学、转录组学和蛋白组学研究;
  2. (2)耐辐射球菌的极端环境适应机理研究;
  3. (3)抗逆性相关功能基因的挖掘和开发利用;
  4. (4)肿瘤细胞耐受性和DNA损
 
发表论文

1. Nakamura T, Zhao Y, Yamagata Y, Hua Y, Yang W (2012) Watching DNA polymerase η make a phosphodiester bond. Nature, 487(7406):196-201. .(IF=35.248)

2. Zhao Y, Biertumpfel C, Hua Y, Hanaoka F, Yang W. Structural Basis of human DNA Polymeraseη Mediated Chemoresistance to Cisplatin. P Natl Acad Sci USA. 2012, 109 (19): 7269-74.(IF=10.591)

3. Hua X, Xu X, Li M, Wang C, Tian B, Hua Y*. Three nth homologs are all required for efficient repair of spontaneous DNA damage in Deinococcus radiodurans. Extremophiles. 2012 May, 16(3):477-84.

4. Sun H, Li M, Xu G, Chen H, Jiao J, Tian B, Wang L, Hua Y*. Regulation of MntH by a Dual Mn(II)- and Fe(II)-Dependent Transcriptional Repressor (DR2539) in Deinococcus radiodurans. PLoS One. 2012, 7(4):e35057.(IF=4.441)

5. Huiming Lu, Huan Chen, Guangzhi Xu, Amir Miraj-Ul-Hussain Shah, Yuejin Hua,* DNA binding is essential for PprI function in response to radiation damage in the extremely radioresistant Deinococcus radiodurans. DNA Repair. 2012, 11(2):139-45. (IF= 4.293)

6. Jiao J, Wang L, Xia W, Li M, Sun H, Xu G, Tian B, Hua Y*. Function and biochemical characterization of RecJ in Deinococcus radiodurans. DNA Repair (Amst). 2012 Apr, 1;11(4):349-56. (IF= 4.293)

7. Wang H, Wang F, Hua X, Ma T, Chen J, Xu X, Wang L, Tian B, Hua Y*. Genetic and biochemical characteristics of the histone-like protein DR0199 in Deinococcus radiodurans. Microbiology. 2012 Apr,158(Pt 4):936-43.

8. Huiming Lu, Huan Chen, Guangzhi Xu, Amir Miraj-Ul-Hussain Shah, Yuejin Hua,* DNA binding is essential for PprI function in response to radiation damage in the extremely radioresistant Deinococcus radiodurans. DNA Repair. 2012 Feb, 1;11(2):139-45. (IF= 4.293)

9. WANG LiangYan, YIN LongFei, XU GuangZhi, LI MingFeng, ZHANG Hui, TIAN Bing, HUA YueJin*. Cooperation of PprI and DrRRA in response to extreme ionizing radiation in Deinococcus radiodurans. Chinese Science Bulletin. 2012, Vol. 57 (1): 98-104.

10. Huiming Lu, Wenrong Xia, Huan Chen, Longfei Yin, Xiaojun Zhao, Guangzhi Xu and Yuejin Hua*, Characterization of the role of DR0171 in transcriptional response to radiation in the extremely radioresistant bacterium Deinococcus radiodurans. Arch. Microbiol. 2011,193(10 ) :741-750.

11. HUA XiaoTing, WANG Hu, WANG Chao, TIAN Bing, and HUA YueJina*, Global effect of site mutagenesis in the β-subunit of RNA polymerase on gene expression in radiation-resistant bacterium Deinococcus radiodurans. Science in China, 2011, 54 (9): 854-862

12. Hong Xu, Li Zheng, Huifang Dai, Mian Zhou, Yuejin Hua*, and Binghui Shen*, Chemicals-induced cancer incidence and underlying mechanisms in Fen1 mutant mice. Oncogene. 2011, 30(9):1072-81 (IF=7.135)

回国-2010

1. Naoki Yamanaka, Yue-Jin Hua, Ladislav Roller, Ivana Spalovská-Valachová, Akira Mizoguchi, Hiroshi Kataoka, and Yoshiaki Tanaka, Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis. P Natl Acad Sci . 2010, 107(5): 2060-2065. (IF=10.591)

2. Hong Xu, Li Zheng, Huifang Dai, Mian Zhou, Yuejin Hua*, and Binghui Shen*, Chemicals-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.Oncogene. 2010, doi: 10.1038/onc.2010.482 (IF=7.135)

3. Bing Tian and Yuejin Hua*, Carotenoid biosynthesis in the extreme bacteria Deinococcus-Thermus. Trends in Microbiol. 2010, 18(11):512-20 (IF=6.894)

4. Guangzhi Xu, Huiming Lu, Liangyan Wang, Huan Chen, Zhenjian Xu, Yihuai Hu, Bing Tian, Yuejin Hua*, DdrB Stimulates Single-stranded DNA Annealing and Facilitates RecA-independent DNA Repair in Deinococcus radiodurans. DNA Repair. 2010, 9: 805-812. (IF=4.199)

5. Bing Tian, Hu Wang, Xiaoqiong Ma, Yaping Hu, Zongtao Sun, Shaochuan Shen, Fei Wang, and Yuejin Hua*, Proteomic analysis of membrane proteins from a radioresistant and moderate thermophilic bacterium Deinococcus geothermalis. Mol. BioSy. 2010, 6, 2068-2077 (IF=4.015)

6. Duohong Sheng, Mingfeng Li, Jiandong Jiao, Wenqiang Deng, Xiehuang Sheng, Yuejin Hua*, Repression of recA induction by RecX is independent of RecA protein in Deinococcus radiodurans. J. Bacteriol. 2010, 192 (13): 3540-3544, (IF=3.94)

7. Hongxing Sun, Guangzhi Xu, Hongdan Zhan, Zongtao Sun, Huan Chen, Bing Tian, Yuejin Hua*, Identification and evaluation the role of manganese efflux protein in Deinococcus radiodurans. BMC Microbiol. 2010, 10(1):319

8. Chen Huan, Wu Rongrong, Xu Guangzhi, Fang Xu, Qiu Xiao, Guo Hongyin, Tian Bing, Hua Yuejin*, DR2539 is a novel DtxR-like regulator of Mn/Fe ion homeostasis and antioxidant enzyme in Deinococcus radiodurans. Biochem. Bioph. Res. Co. 2010, 396(2): 413-8.

9. Hu Y, Tian B, Xu G, Yin L, Hua X, Lin J, Hua Y*, Characteristics of nuclease activity of the SbcCD complex from Deinococcus radiodurans. J Biochem. 2010, 147(3):307-15.

10. Longfei Yin, Liangyan Wang, Huiming Lu, Guangzhi Xu, Huan Chen, Hongdan Zhan, Bing Tian*, Yuejin Hua*,DRA0336, another OxyR homolog, involved in the antioxidation mechanisms in Deinococcus radiodurans. J. Microbiol. 2010, PMID: 20799089.

11. Xiaoting Hua, Chao Wang, Ye Zhao, Hu Wang, Lifen Huang, Guangzhi Xu, Mingfeng Li, Yuan Wang, Bing Tian, and Yuejin Hua*, Both OB Folds of Single-Stranded DNA-Binding Protein Are Essential for Its ssDNA Binding Activity in Deinococcus radiodurans. Protein & Peptide Lett. 2010, 17, 1189-1197.

12. Lu H, Gao G, Xu G, Fan L, Yin L, Shen B, Hua Y. .Deinococcus radiodurans PprI switches on DNA damage-response and cellular survival networks after radiation damage. Mol Cell Proteomics. 2009, 8, 484-491 (IF=8.791)

13. Zongtao Sun, Shaochuan Shen, Chao Wang, Hu Wang, Yaping Hu, Jiandong Jiao, Tingting Ma,Bing Tian and Yuejin Hua. A novel carotenoid 1,2-hydratase (CruF) from two species of the non-photosynthetic bacterium Deinococcus. Microbiology-SGM. 2009, 155: 2775-2783.

14. Zongtao Sun, Shaochuan Shen, Bing Tian, Hu Wang, Zhenjian Xu, Liangyan Wang, Yuejin Hua. Functional analysis of γ-carotene ketolase involved in the carotenoid biosynthesis of Deinococcus radiodurans. FEMS Microbiology Letters. 2009, 301: 21–27

15. Bing Tian, Zongtao Sun, Shaochuan Shen, Hu Wang, Jiandong Jiao, Liangyan Wang, Yihuai Hu, Yuejin Hua. Effects of carotenoids from Deinococcus radiodurans on protein oxidation. Letters In Applied Microbiology. 2009, 49(6): 689-694

16. Lin J, Hu Y, Tian B, Hua Y. Evolution of double MutT/Nudix domain-containing proteins: similar domain architectures from independent gene duplication-fusion events.J Genet Genomics. 2009, 36(10):603-610.

17. Wu Y, Chen W, Zhao Y, Xu H, Hua Y.Involvement of RecG in H2O2-induced damage repair in Deinococcus radiodurans. Can J Microbiol. 2009, 55(7):841-8.

18. Chen H, Huang L, Hua X, Yin L, Hu Y, Wang C, Chen W, Yu X, Xu Z, Tian B, Hu S, Hua Y. Pleiotropic effects of RecQ in Deinococcus radiodurans. Genomics. 2009 Nov; 94(5):333-340.

19. Ying N., Tachiiri Y, Tsuchiya H, and Hua Y. Responses of tiller growth and related genes expression in rice to red and blue radiation. Biologia Plantarum. 2009, 53(1): 188-190

20. Yihuai Hu, Bing Tian, Guangzhi Xu, Longfei Yin, Xiaoting Hua, Jun Lin, and Yuejin Hua. Characteristics of Nuclease Activity of the SbcCD Complex from Deinococcus radiodurans. Journal of Biochemisty. 2009,147(3): 307–315

21. Wang L, Xu G, Chen H, Xu N, Tian B, Hua Y, DrRRA: a novel response regulator essential for the extreme radioresistance of Deinococcus radiodurans. Mol. Microbiol., 2008, 67(6):1211-1222. (IF=5.462)

22. Hua X, Huang L, Tian B, Hua YJ. Involvement of recQ in the ultraviolet damage repair pathway in Deinococcus radiodurans. Mutat Res.-Fund Mol M. 2008, 641(1-2):48-53.

23. Xu G, Wang L, Chen H, Lu H, Ying N, Tian B, and Hua YJ, RecO is essential for DNA damage repair in Deinococcus radiodurans, J. Bacteriol. 2008, 190 (7): 2624–2628. (IF=3.636)

24. Huan Chen, Guangzhi Xu, Ye Zhao, Bing Tian, Huiming Lu, Xiaoming Yu, Songnian Hu, Yuejin Hua, A Novel OxyR Sensor and Regulator of Hydrogen Peroxide Stress with One Cysteine Residue in Deinococcus radiodurans, PloS ONE, 2008, 3 (2): e1602 (IF=4.351)

25. Bing Tian, Zongtao Sun, Zhenjian Xu, Shaochuan Shen, Hu Wang, Yuejin Hua, Carotenoid 3’,4’ desaturase involved in the carotenoid biosynthesis of the extremely radioresistant bacterium Deinococcus radiodurans. Microbiology. 2008,154, 3697-3706.

 

26. Jun Lin, Yi-Huai Hu, Bing Tian, and Yuejin Hua, Structural and Functional Diversity of Nudix Fold, Protein Pept. Lett. 2008, 15 (1): 108-112.

27. Nanjiao Ying, Zhiguo Zheng, Hong Xu, Bing Tian, Yuejin Hua, Extracellular proteome changes of Deinococcus radiodurans under γ-irradiation stress conditions, Protein Pept. Lett., 2008;15(6):595-599.

28. Donghai Le, Jianfu Shen, Lifen Huang, Guanjun Gao, Huiming Lu, Zhenjian Xu, Bing Tian, Yuejin Hua, Biochemical characterization of two DNA ligases from Deinococcus radiodurans. Protein Pept. Lett. 2008,15(6):600-605.

29. Guanjun Gao, Lu Fan, Huiming Lu, and Yuejin Hua, Engineering Deinococcus radiodurans into biosensor for monitoring radioactivity and genotoxicity in environment. Chin. Sci. Bul. 2008, 53 (11): 1675-1681.

30. Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, Hua Y. Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. DNA Repair. 2007, 6(2):167-76. (IF=5.018)

31. Bing Tian, Zhenjian Xu, Zongtao Sun, Jun Lin, Yuejin Hua. Evaluation of the antioxidant effects of carotenoids from Deinococcus radiodurans through targeted mutagenesis, chemiluminescence, and DNA damage analyses. Biochimica et Biophysica Acta- General Subjects. 2007, 1770: 902-911.

32. Bing Tian, Zongtao Sun, Zhenjian Xu, Yuejin Hua. Chemiluminescence analysis of the prooxidant and antioxidant effects of epigallocatechin-3-gallate. Asia Pacific Journal of Clinical Nutrition. 2007,16 (Suppl 1):153-157.

33. Zhenjian Xu,Bing Tian,Zongtao Sun, Jun Lin, Yuejin Hua, Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans. Microbiology-SGM. 2007, 153: 1642-1652 .

 

34. Wu Yuanyuan, TIAN Bing, HUA Yuejin. Dr1127: A novel gene of Deinococcus radiodurans responsible for oxidative stress. Chinese Science Bulletin. 2007, 52(15): 2081-2087.

 

35. Jun Lin, Zhong-Zhong Chen, Bing tian, Yue-Jin Hua. Origin and Evolutionary Pathways of RecX. GENE. 2007, 387(1-2): 15-20

36. Hu Yihuai, Ma Chenyu, Tian Bing, Lin Jun, Hua Yuejin. Function analysis of the sbcD (dr1921) gene of the extremely radioresistant bacterium Deinococcus radiodurans. Chinese Science Bulletin. 2007, 52(18): 2506-2513.

37. Chen Huan, Xu Zhenjian, Tian Bing, Chen Weiwei, Hu Songnian and Hua Yuejin. Transcriptional profile in response to ionizing radiation at low dose in Deinococcus radiodurans. Progress in Natural Science. 2007, 17(5): 529-536.

38. Gao G, Lu H, Yin L, Hua Y. Ring-like nucleoid does not play a key role in radioresistance of Deinococcus radiodurans. Science in China, Series C: Life Sciences. 2007,50(4):525-9.

39. Zhou Q, Zhang X, Xu H, Xu B, Hua Y. A new role of Deinococcus radiodurans RecD in antioxidant pathway. FEMS Microbiology Letters. 2007,271(1):118-25.

40. Zhou Q, Chen W, Zhang X, Xu H, Xu B, Hua Y. Characterization of the double mutant of Deinococcus radiodurans lexA1 and lexA2. Chinese Science Bulletin. 2007;52(8):1046-52.

41. Zhou Q, Zhang X, Xu H, Xu B, Hua Y. RadA: A protein involved in DNA damage repair processes of Deinococcus radiodurans R1. Chinese Science Bulletin. 2006;51(24):2993-9.

42. Gao G, Le D, Huang L, Lu H, Narumi I, Hua Y. Internal promoter characterization and expression of the Deinococcus radiodurans pprI-folP gene cluster. FEMS Microbiology Letters. 2006, 257(2):195-201.

43. Chunchao Zhang, Jianfeng Wei, Zhiguo Zheng, Nanjiao Ying, and Yuejin Hua * . Proteomic analysis of Deinococcus radiodurans recovering from γ -radiation. Proteomics. 2005, Vol. 5, 138–143.

44. Duohong Sheng, Zhiguo Zheng, Bing Tian, Binghui Shen, and Yuejin Hua *. Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans. DNA Repair. 2005, 4(6): 671-678. (IF= 4.293)

45. Duohong Sheng; Bing Tian, Zhenjian Xu, Zhiguo Zheng, and Yuejin Hua *. RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans . FEMS Microbiol. Let. 2005, 244(2): 251-257.

46. Bing Tian and Y.J. Hua *. Concentration dependence of prooxidant and antioxidant effects of aloin and aloe emodin on DNA. Food Chem. 2005, 91(3): 413-418.

47. Lili Liu, Jianjun Shi, Xiyue Zhao, Yuejin Hua *. Dynamics of transfer and distribution of 95Zr in the broadbean-soil ecosystem. J. Environ. Radioactiv. 2005, 80(2):217-223.

48. Guanjun Gao, Huiming Lu, Lifeng Huang & Yuejin Hua *. Construction of DNA damage response gene pprI function- deficient and function-com- plementary mutants in Deinococcus radiodurans. Chin. Sci. Bul. 2005, 50(1): 1-6.

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